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January 1948

L'acetilcolina nelle sindromi schizofreniche. Interpretazione patogenetica della dissociazione mentale e sua applicazione terapeutica.

Arch NeurPsych. 1948;59(1):138-139. doi:10.1001/archneurpsyc.1948.02300360148015

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Fiamberti is director of the neuropsychiatric hospital at Varese; in 1937 he introduced the transorbital method of lobotomy. He states that in 1935 he produced convulsions in experimental animals by intracisternal injections of acetylcholine and in 1937 began treating psychotic patients by rapid intravenous injection of the same drug. He favors use of acetylcholine in shock therapy because of its theoretic implications, as well as its practical convenience and safety. In his monograph, which has a good summary in English, he reports results in 311 cases of schizophrenia. Follow-up studies of 120 cases at the end of four years show that the results are fairly stable. The rate of recovery was 68 per cent for persons sick less than one year, 28 per cent for those sick from one to three years and 17 per cent for those sick more than three years. Many of the patients whom the therapy