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March 1948

PERIPHERAL NEURITIS COMPLICATING MULTIPLE MYELOMA

Author Affiliations

NEW YORK

From the Second Medical Service, Mount Sinai Hospital.

Arch NeurPsych. 1948;59(3):378-384. doi:10.1001/archneurpsyc.1948.02300380107009
Abstract

IT IS well known that patients with multiple myeloma may suffer mechanical injury to neural structures as a result of compression of these tissues directly, or of their blood supply, by the tumor itself or by the pathologic fractures which it causes. Forty per cent of patients with myeloma1 have this complication in the form of lesions of the cord,2 lesions of the nerve roots,3 compression of the spinal ganglia4 or intracranial lesions.5 Another type of neural injury, which does not appear to be due to mechanical factors, has received little attention.

Whereas Davison and Balser2f were able to demonstrate pressure on neural structures or their blood supply by the myeloma or fractured vertebrae in most of their cases, the neurologic complications in 1 case could not be accounted for on this basis. In this case there was peripheral neuritis in the upper extremities

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