SCHLESINGER1 in May 1946 reported the effects of d-tubocurarine chloride (a suspension in peanut oil-white wax mixture) in 11 patients with muscular spasm due to trauma to the spinal cord. He reported improvement in function and relaxation of the involved extremities lasting up to three days after injection with doses ranging from 0.5 to 2.5 cc. The patients in this series had relatively acute conditions and were seen in the outpatient department. The same author2 in October 1946 reported results of tubocurarine with patients presenting (a) muscle spasm due to trauma, myositis and arthritis; (b) spasticity due to degenerative diseases, and (c) dystonia, athetosis and rigidity. He concluded that "spasm, spasticity and rigidity are affected in order of decreasing efficiency." He stated that in cases of spastic paraplegia curare in oil has "proved a valuable adjunct to treatment." In this paper we report results with the same
NATHANSON M, LESSER S, GORDON G, GRESSER N. INTRAMUSCULAR USE OF TUBOCURARINE IN CHRONIC SPASTICITY DUE TO DISEASE OF CENTRAL NERVOUS SYSTEM: Further Clinical Investigation. Arch NeurPsych. 1948;60(1):77–80. doi:10.1001/archneurpsyc.1948.02310010083007
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