[Skip to Navigation]
February 1949

Total Protein, Globulin and Albumin in Lumbar Fluid in Cryptogenic Epilepsy.

Arch NeurPsych. 1949;61(2):226. doi:10.1001/archneurpsyc.1949.02310080130015

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.


The author has measured the total protein and globulin-albumin quotient in 133 cases of epilepsy (21 of the "symptomatic" type) and in 67 control cases. The data are presented in detail in 15 tables and 4 charts and are discussed intelligently against a background of more than 200 references. The method of Izikowitz was employed. In 5.5 per cent of 100 cases of cryptogenic epilepsy, the total protein was above the normal limit of 65 mg. per hundred cubic centimeters for males and 49 mg. for females. Among the male subjects, mean values were as follows: cryptogenic epilepsy, 41.32 mg.; symptomatic epilepsy, 38.71 mg.; normal subjects (Izikowitz), 39.46 mg., per hundred cubic centimeters. In the same groups, the globulin-albumin quotient was below normal (0.14 for male and 0.13 for female patients) in 10 per cent. The mean quotient for male patients with cryptogenic epilepsy was 0.2103, for male patients with