EVIDENCES OF VASCULAR DISORDER IN CASES OF MULTIPLE SCLEROSIS
SINCE the time of Rindfleisch,1 disturbances in circulation have been described as a part of the histologic picture of multiple sclerosis by the majority of observers. Some pathologists (Ribbert,2 Borst,3 Williamson,4 Klingman5) have ascribed an etiologic significance to the alterations observed, and one of us (T. J. P.), with various collaborators, has attempted a systematic survey of the hypothesis that the characteristic lesions are the result of vascular closure. Spotty areas of demyelination, with relative preservation of axis-cylinders and a purely ectodermal type of repair, may be produced by experimental venular obstruction,6 or may be observed in conjunction with a variety of lesions which embarrass the venous return.7 Thrombi are observed in or adjacent to the lesions in about 36 per cent of cases.8 This observation has subsequently been confirmed by Dow and
CHIAVACCI LV, PUTNAM TJ. CAPILLAROSCOPIC OBSERVATIONS IN CASES OF MULTIPLE SCLEROSIS. Arch NeurPsych. 1949;61(5):577–582. doi:10.1001/archneurpsyc.1949.02310110112007
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