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September 1949

MUSCULAR ATROPHY AND PSEUDOLOGIA FANTASTICA ASSOCIATED WITH ISLET CELL ADENOMA OF THE PANCREAS

Author Affiliations

Consultant in Psychiatry, Veterans Administration Hospital, Fort Howard, Md. BALTIMORE; Chief of the Surgical Service, Veterans Administration Hospital; Chief of the Medical Service, Veterans Administration Hospital FORT HOWARD, MD.; Junior Medical Officer, Neuropsychiatric Service, Veterans Administration Hospital PERRY POINT, MD.

From the Veterans Administration Hospitals, Fort Howard, Md., and Perry Point, Md.

Arch NeurPsych. 1949;62(3):304-313. doi:10.1001/archneurpsyc.1949.02310150051006
Abstract

A CASE is reported in which prolonged hypoglycemia due to an islet cell tumor of the pancreas was accompanied with an unusual array of symptoms due to widespread damage of the central nervous system. The patient had had repeated convulsions, periods of confusion and excitement, ataxia, muscular atrophy, intellectual impairment and pseudologia fantastica. After removal of the pancreatic adenoma, all abnormalities except the muscular atrophy disappeared. It has been recognized that deprivation of glucose essential for metabolism of the nerve cells can cause irreversible damage of the brain and spinal cord, but involvement of the central nervous system as extensive as in the present case has rarely been reported. Both the relationship of a syndrome resembling progressive muscular atrophy to spontaneous hypoglycemia and the recovery of a patient with pseudologia fantastica seem of unusual interest.

REPORT OF A CASE  The patient, a 23 year old veteran, came to our attention

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