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October 1949

RECURRENT HYPERTENSIVE CEREBRAL THROMBOSIS: Clinicopathologic Analysis of Six Cases with Discussion of Pathogenesis

Author Affiliations

Pathologist, The South Side Hospital PITTSBURGH

From the State Hospital for Mental Diseases, Howard, R. I.

Arch NeurPsych. 1949;62(4):445-478. doi:10.1001/archneurpsyc.1949.02310160065005

SINCE Goldblatt's1 famous experiments on dogs resulting in the production of permanent hypertension similar to hypertensive cardiovascular disease in man, attention has been focused more or less constantly on the kidneys as one of the most important sources of the disease. The role of the brain has received scant attention perhaps because it has been assumed that the cerebral lesions in hypertensive cardiovascular disease were secondary to those in the kidneys.

There is a certain group of patients with hypertension whose chief symptoms are cerebral and in whom evidence of renal involvement may develop only late in the disease. In general, the nature of the illness is not recognized or is incorrectly diagnosed because of the variability of the presenting symptoms. According to Alvarez,2 it is a specific syndrome which is not found described to any extent in the books or journals and which is seldom discussed at