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October 1949

TECHNIC OF CORTICAL EXCISION: An Experimental Study of Postoperative Cicatrization

Author Affiliations


From the Department of Neurology and Neurosurgery of McGill University and the Montreal Neurological Institute.

Arch NeurPsych. 1949;62(4):479-492. doi:10.1001/archneurpsyc.1949.02310160099006

THE PROBLEM of cicatrization after cortical excision or incision is one which faces the neurosurgeon constantly, whether the tissue he handles is neoplastic or cicatricial. The recent introduction of surgical procedures such as lobotomy, convolectomy and topectomy for the treatment of neuroses and psychoses has increased the number of surgically produced cicatrices. Since a cerebral cicatrix is a potential epileptogenic lesion, it is important to know what factors enter into its production. Therefore, the following series of experiments were performed to determine which technic of excision produces a better scar from the standpoint of gliosis and tendency to become epileptogenic.


Pathology.—  Tschistowitsch1 used a platinum needle to produce stab wounds in brains of dogs and pigeons and studied the brains three to one hundred and thirty days after injury. He concluded that connective tissue elements of pia and blood vessels played the chief role in scar

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