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Physiology and Biochemistry
ACETYLCHOLINE AND Neuromuscular TRANSMISSION. MARIANNE Fillenz and Mary Hanafin, J. Neurophysiol. 10:189 (May) 1947.Fillenz and Hanafin produced complete block of neuromuscular transmission by soaking the frog's sartorius muscle in a 1: 500,000 solution of acetylcholine chloride in the presence of a 1: 100,000 solution of neostigmine. Under these conditions a nerve impulse still sets up an end plate potential, which in ideal circumstances is slightly larger than the curare end plate potential and has a time course resembling that of the curare-neostigmine end plate potential.The end plate potential set up by rapid repetitive stimulation exhibits on cessation of stimulation rather discrete fast and slowly decaying components. The slow component is small with the curare end plate potential and is selectively increased by neostigmine. It is also large with the acetylcholine end plate potential. Forster, Philadelphia.Acetylcholine and Synaptic Transmission in the Spinal Cord. J.
Bernard J. Alpers. Abstracts from Current Literature. Arch NeurPsych. 1949;62(4):503–509. doi:10.1001/archneurpsyc.1949.02310160123008