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November 1949

MEDULLOBLASTOMA: Report of a Case with Discussion of Origin

Author Affiliations


From the Department of Pathology, University of Arkansas School of Medicine and University Hospital.

Arch NeurPsych. 1949;62(5):653-662. doi:10.1001/archneurpsyc.1949.02310170128011

THE CLINICAL course and the pathologic anatomy of the medulloblastoma have been repeatedly reported and clearly defined since the tumor was described to the American Neurological Association by Bailey and Cushing in 1924.1 However, an interesting case of this tumor has directed my attention to the extensive study and conflicting nature of the theories dealing with its origin. The undifferentiated nature of the cells composing the neoplasm led the original authors to the belief that these cells, if of ectodermal origin, must be akin to the indifferenten Zellen of Schaper. Such cells had been previously identified (Pfleger) in heterotopic cellular groups in the region of the fourth ventricle, and Bailey and Cushing expressed the belief that "if such an isolated and retarded group of undifferentiated cells should undergo a neoplastic transformation, just such a tumor as we have described might be expected to result."1 Although this theory is