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December 1949


Author Affiliations


From the Department of Neurology, Columbia University College of Physicians and Surgeons; Montefiore Hospital, and the Neurological Institute of New York.

Arch NeurPsych. 1949;62(6):784-793. doi:10.1001/archneurpsyc.1949.02310180085010

THE DURATION of life after onset of symptoms in patients with multiple sclerosis is quite variable. The reports in the literature give ten to thirteen years as the average duration of life in both clinical cases and in cases verified at autopsy.1 Survival for twenty to thirty years is not unusual but survival over thirty years is rare. Bramwelllb reported 23 cases and Heine2 noted 12 cases of survival for twenty to thirty years. In a series of 170 clinical cases, Bramwell described 7 cases of survival for thirty years or more: in 3 cases for thirty years and in 1 case each for thirty-two, thirty-four, thirty-five and thirtyseven years.1b Wechsler,3 in a review of 1,970 clinical cases, noted no case in which the patient lived beyond thirty years except for those cited by Bramwell. Wilson4 incorrectly cited Adie as listing a case of fifty-four

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