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January 1950

STUDIES ON HEADACHE: 1. Effects of Carbon Dioxide—Oxygen Mixtures Given During Preheadache Phase of the Migraine Attack 2. Further Analysis of the Pain Mechanisms in Headache

Arch NeurPsych. 1950;63(1):42-51. doi:10.1001/archneurpsyc.1950.02310190048002

A LARGE body of clinical and experimental studies have illuminated some of the bodily changes which take place during an attack of migraine.1 The pain of this headache is known to arise from dilated arteries either inside or outside the head or both. Certain of the preheadache phenomena have been studied and have been shown to be the result of cerebral vasoconstriction.

It is the purpose of this paper to describe further experiments which have been carried out in an attempt to clarify the nature of the vasoconstrictor and vasodilator phases of the attack.

EFFECTS OF CARBON DIOXIDE-OXYGEN MIXTURE GIVEN DURING PREHEADACHE (VASOCONSTRICTOR) STAGE  Certain of the preheadache phenomena have been shown to be the result of vasoconstriction in strategic areas of the brain or retina. A physician who had loss of segments of his visual fields prior to headache was able transiently to restore his vision to normal