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January 1950

Die multiple Sklerose des Menschen.

Arch NeurPsych. 1950;63(1):190. doi:10.1001/archneurpsyc.1950.02310190196020

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Schaltenbrand's book on multiple sclerosis consists of a review of the literature and a critical appraisal of past work and of various hypotheses concerning the disease, as well as original reports on the author's own experimental and therapeutic work. The book is divided into five major chapters.

Chapter 1 is concerned with manifestations of multiple sclerosis. This chapter includes a review of the geographic distribution and incidence of multiple sclerosis, the typical manifestations of the disease, methods for early diagnosis by objective measurement of the tonic state of the muscles, autopsy findings and the relation of multiple sclerosis to other demyelinating diseases.

Chapter 2, entitled "Theories Concerning the Causation of Multiple Sclerosis," deals with the hereditary aspects of the disease, Putnam's thrombosis theory, the enzyme theory, the infection theory and the allergic theory. In the author's opinion, the weight of evidence is regarded as supporting the theory of infection. Chapter

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