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May 1950

INTERACTION OF EFFECTS OF ACETYLCHOLINE AND ADENOSINE TRIPHOSPHATE ON ELECTRICAL ACTIVITY OF CAT CEREBRAL CORTEX

Arch NeurPsych. 1950;63(5):766-773. doi:10.1001/archneurpsyc.1950.02310230088008
Abstract

IN THE course of an investigation into effects on the electrical activity of the cat cerebral cortex exerted by substances known to be present in nerve tissue, we have studied the interaction between acetylcholine and adenosine triphosphate after their successive local application to the cortex. We consider the findings suggestive enough to justify a separate description. Our attention was directed to the investigation of this interaction by the demonstration of Nachmansohn1 that adenosine triphosphate plays a role in the synthesis of acetylcholine by nerve tissue, under certain conditions, in vitro.

METHOD  The results of experiments on 22 mongrel adult cats are reported here. Anesthesia was induced by the intraperitoneal injection of pentobarbital sodium, U. S. P., in a dose of 0.060 Gm. (1 grain) per kilogram of body weight. If, during a long experiment, the need arose for further anesthesia, an intraperitoneal injection of about 0.016 Gm. of pentobarbital

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