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July 1950

SECTION OF U FIBERS OF MOTOR CORTEX IN CASES OF PARALYSIS AGITANS (PARKINSON'S DISEASE)Report of Nine Cases

Arch NeurPsych. 1950;64(1):57-59. doi:10.1001/archneurpsyc.1950.02310250063004
Abstract

AT THE meeting of the Harvey Cushing Society in San Francisco in April 1948, Russell Meyer reported the successful relief of the symptoms in a patient with hemiballismus by an incision in area 4 of Brodmann on the side opposite the movement. The incision was 2.5 cm. deep and 6 cm. long, without any removal of cortical tissue. It was designed to interrupt the U fibers connecting area 4 with area 6.

Dr. Barry Wyke, of Sydney, Australia, who heard this presentation and saw the motion picture, was so impressed with the results that later, at the meeting of the American Neurological Association in June 1948, he suggested to several neurologists and neurosurgeons that a somewhat similar operation might relieve the rigidity and tremor of paralysis agitans (Parkinson's disease).1 The plan was to locate area 4s by stimulation at operation. Such stimulation was said to cause cessation of tremor

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