I. COMPARISON OF SCHIZOPHRENIC AND NORMAL SUBJECTS
THE PROBLEM of the etiology and pathogenesis of schizophrenia has been the object of many experimental attacks, including a search for an underlying somatic, or "organic," factor. Those who have made inquiries along this line have brought to light much evidence of physiological abnormality in schizophrenia, associated particularly with the function of the autonomic nervous system.Hoskins,1 in 1946, published the results of many years of physiological research, comprising studies of endocrine function, metabolism, circulation and various homeostatic mechanisms. Many other workers have contributed pertinent data to this subject. The over-all impression gained from a review of this literature is that the chief physiological defect in schizophrenia is in the sphere of homeostasis, with diminished adaptability to both endogenous and exogenous stimuli. Dysfunction at the cortical or the hypothalamic level has been implicated most frequently in the explanation of the observed impairment
BUCK CW, CARSCALLEN HB, HOBBS GE. TEMPERATURE REGULATION IN SCHIZOPHRENIA: I. Comparison of Schizophrenic and Normal Subjects II. Analysis by Duration of Psychosis. AMA Arch NeurPsych. 1950;64(6):828–842. doi:https://doi.org/10.1001/archneurpsyc.1950.02310300075007
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