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May 1951


AMA Arch NeurPsych. 1951;65(5):581-588. doi:10.1001/archneurpsyc.1951.02320050038004

STOLL1 studied the effects of lysergic acid diethylamide (LSD-25) in both psychotic and normal subjects. Condrau2 and others reported their results of administration of lysergic acid diethylamide to various types of subjects and in general confirmed the findings of Stoll.

For details of the chemistry of the ergot alkaloids, we refer to a more recent, comprehensive work by Stoll.3 It should be mentioned in passing that all lysergic acid alkaloids have lysergic acid as a base. This substance is a multiple, active, polycyclic, nitrogenous carboxylic acid, which so far has not been synthesized. The natural ergot alkaloids contain d-lysergic acid and may be divided into two groups— the ergotamine-ergotoxine group, on the one hand, and the ergonovine group, on the other. In the former group d-lysergic acid is combined with a manifold peptid, whereas the latter group comprises the mono acid amides of the d