GARIN, Plauchu and Masson1 reported four attacks of subarachnoid hemorrhage in a case of melanocarcinoma of the jaw with multiple metastatic melanomas in the meninges and brain, observed at necropsy. Other investigators have since commented on the occurrence of bloody or xanthochromic cerebrospinal fluid in cases both of primary and of secondary melanoma of the brain. Schnitker and Ayer2 found grossly bloody fluid in three cases, xanthochromic fluid in two cases and clear fluid in seven cases of a series of primary melanomas of the nervous system. Loewenberg3 stated that in 14 cases of metastatic melanoma of the brain collected from the literature, including six of his own, the cerebrospinal fluid was distinctly xanthochromic in seven and slightly yellowish in one; in several instances it was bloody. Wortis and Wortis4 advised:
Whenever bloody or xanthochromic fluid is found in a patient who has melanomatous tumors of
MADONICK MJ, SAVITSKY N. SUBARACHNOID HEMORRHAGE IN MELANOMA OF THE BRAIN. AMA Arch NeurPsych. 1951;65(5):628–636. doi:10.1001/archneurpsyc.1951.02320050085010
Customize your JAMA Network experience by selecting one or more topics from the list below.