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June 1951

ENCEPHALOPATHY ASSOCIATED WITH ACUTE DIFFUSE PLATELET THROMBOSISReport of a Case

Author Affiliations

HOUSTON, TEXAS

From the Department of Neuropsychiatry, Baylor University College of Medicine, and the Pathology Section of the Memorial Hospital.

AMA Arch NeurPsych. 1951;65(6):672-679. doi:10.1001/archneurpsyc.1951.02320060015002
Abstract

CLINICAL and pathological involvement of the central nervous system has been noted as a prominent feature of acute diffuse platelet thrombosis (disseminated arteriolar and capillary platelet thrombosis; thrombotic thrombocytopenic purpura; acute thrombocytopenic purpura; thrombocytic acroangiothrombosis), which was first described by Moschcowitz1 in 1925 and established as a disease entity by Baehr, Klemperer and Schifrin2 in 1936. This is a rare disease, and only 23 cases have been reported. Only one of these reports has appeared in a neuropsychiatric journal,3 and the condition has not been mentioned in any of the modern textbooks of neuropathology, neurology or psychiatry. With this in view, we report this additional case of a disease which has been delineated rather extensively from the pathological standpoint, in order to emphasize the clinical, neurologic and psychiatric aspects. Since antemortem diagnosis of the disease has been reported only in one instance, it is felt that neuropsychiatrists

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