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June 1951


AMA Arch NeurPsych. 1951;65(6):683-702. doi:10.1001/archneurpsyc.1951.02320060026004

TUBEROUS sclerosis (epiloia) is generally considered a developmental tissue dysplasia, being an expression of anomalous development beginning in the very early months of fetal life. This disease is usually classified as belonging to the group of neurocutaneous syndromes. It is certainly congenital, and several cases have been reported which indicate that there may be a hereditary or familial component. Ross and I1 reported that a study of the hereditary factors in this condition demonstrated these factors to be no more outstanding in patients with tuberous sclerosis than in other types of institutional epileptics.

A patient showing the characteristic symptom triad of tuberous sclerosis was admitted to the Caro State Hospital for Epileptics on April 12, 1948. She was brought to the institution by her parents and an older sister. It was immediately noticed that the female members of the family presented an unusual occurrence of this disease. The study