IN RECENT years the exfoliative-cell diagnosis of neoplasms having a free surface has been advocated by Papanicolaou1 and others,2 using the fixed-smear technique. This method has been utilized in the detection of uterine and cervical carcinoma by examination of the vaginal and cervical smears; in the diagnosis of carcinoma of the laryngo-tracheo-broncho-pulmonary tree by cytologic study of sputum and bronchial secretions; in the diagnosis of malignant changes in the esophageal-gastric-pancreatic-biliary tract by analysis of aspirated gastric-duodenalbiliary contents; in the detection of renal, vesical, and prostatic carcinoma by the study of urethral and bladder urine and prostatic-secretion smears; in the diagnosis of primary and metastatic neoplasms of the pleural and peritoneal cavities by a study of the effusions associated therewith; in the detection of malignant growths of the colon and rectum and of the skin by an analysis of the mucoid material and imprints obtained from the feces and
PLATT WR. EXFOLIATIVE-CELL DIAGNOSIS OF CENTRAL NERVOUS SYSTEM LESIONS. AMA Arch NeurPsych. 1951;66(2):119–144. doi:10.1001/archneurpsyc.1951.02320080003001
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