RECENT investigations by Hoagland and Pincus1 have emphasized the defective physiological responses of the schizophrenic patient to adrenocortical stimulation. Altschule and co-workers2 have reported essentially normal physiological responses to corticotrophin in schizophrenic patients, with the exception of suggestive greater-than-normal changes in glucose tolerance. In an attempt to evaluate the relationship between adrenocortical activity and the psychological state, we administered corticotrophin in large doses to six patients (three men and three women) with schizophrenia. Significant data concerning these patients are presented in the accompanying table.
All the patients were observed in a control period varying from two to four weeks before the administration of the corticotrophin. The influence of placebos and other drugs, such as amobarbital (amytal®), d-desoxyephedrine hydrochloride (pervitin®), amphetamine, and mescaline, was studied during the control period, or after a suitable time had elapsed after the corticotrophin was discontinued. The corticotrophin3 was given
GLASER GH, HOCH PH. OBSERVATIONS ON EFFECT OF CORTICOTROPHIN IN SCHIZOPHRENIA: A Preliminary Report. AMA Arch NeurPsych. 1951;66(6):697–699. doi:10.1001/archneurpsyc.1951.02320120030003
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