SINCE Boeck1 first published his original description of sarcoid, in 1899, approximately 1,500 cases have been recorded in the literature. The disease has been reported from many European countries and in increasing numbers from this country, where a high percentage of patients are Negroes.
In general, the disease is a chronic, low-grade, granulomatous process of unknown cause, with fever, malaise, loss of weight, anorexia, and special symptoms or signs referable to involvement of one or more organs of the body. Common manifestations are lesions of the skin, enlargement of lymph nodes, parotitis, visual loss associated with uveitis (the last two being sometimes referred to as uveoparotid fever), and lesions in the lung, often found on routine chest films without symptoms. Elevation of the blood globulin, x-ray changes in the lungs and phalanges, a negative reaction to the tuberculin test, and a positive reaction to the Kveim test are the
PENNELL WH. BOECK'S SARCOID WITH INVOLVEMENT OF THE CENTRAL NERVOUS SYSTEM. AMA Arch NeurPsych. 1951;66(6):728–737. doi:10.1001/archneurpsyc.1951.02320120061008
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