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July 1952

STATISTICAL CONTROL STUDIES IN NEUROLOGYIII. The Hoffmann Sign

AMA Arch NeurPsych. 1952;68(1):109-115. doi:10.1001/archneurpsyc.1952.02320190115011
Abstract

VARIOUS investigators have expressed divergent opinions concerning the incidence of the Hoffmann sign, its explanation, and its significance. Hence it was considered advisable to review the subject and to study the significance of this sign in a large population.

REVIEW OF LITERATURE  Previous writers may be classified under three groups on the basis of their position as to the significance of the Hoffmann sign: Group 1 consists of those who consider the Hoffmann sign a pathologic sign, indicating pyramidal-tract involvement; Group 2 consists of those who believe that the Hoffmann sign indicates pyramidal-tract involvement but that, owing to its frequent presence in other conditions, its clinical value is doubtful; Group 3 consists of those who do not consider the Hoffmann sign as pathologic or of any clinical value.

Group 1.—  Keyser,1 who preferred the term "digital reflex," stated that the Hoffmann sign is found practically always present in cases

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