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July 1952

The Submicroscopic Organization of Vertebrate Nerve Fibers as Revealed by Electron Microscopy.

AMA Arch NeurPsych. 1952;68(1):163. doi:10.1001/archneurpsyc.1952.02320190169016

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This monograph consists of a series of papers published from the Institute for Cell Research at Karolinska Institutet, Stockholm. The care and ingenuity devoted to the study of the topic are remarkable. When the individual nerve fiber with its sheath is magnified 20,000 diameters, it appears invested on its outer aspect with a thin reticulum of collagen. The neurilemma covers a myelin sheath made up of a series of some fifty thin-walled tubes fitting concentrically one within another and separated by irregular oval crevices that are distributed throughout the sheath. There is also an internal fibrous membrane, corresponding to the axolemma. The axon itself has a reticulated appearance and is made up of filaments of indefinite length, having a diameter of 100 to 200 Å, with regularly spaced axial discontinuities. "These filaments show a predominantly longitudinal arrangement within the fiber and can aggregate to form compact bundles resembling neurofibrils. Dense

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