ACUTE expanding closed cerebral lesions in patients present many problems, l related principally to pathogenesis of symptoms and choice of therapy. Much conflict of opinion about these matters has arisen because they cannot be studied in complicated human cases in a quantitative way. A method for the experimental production of acute closed cerebral lesions in animals has made it possible to conduct quantitative studies.1 The method was refined so that discrete intracerebral lesions of desired volume could be reproduced in successive animals without interrupting the continuity of the calvaria or introducing variables incidental to mechanical trauma.2
This report is concerned with a description of the method and its use in the study of relations of volume per cent of cerebral damage to clinical manifestations, not only in untreated animals but also in animals treated with intravenous injections of hypertonic dextrose solution or surgical decompression.
Instrument for Production
GEORGE M. HASS, C. BRUCE TAYLOR. QUANTITATIVE STUDIES OF EXPERIMENTAL PRODUCTION AND TREATMENT OF ACUTE CLOSED CEREBRAL INJURY. AMA Arch NeurPsych. 1953;69(2):145–170. doi:10.1001/archneurpsyc.1953.02320260003001