THE ROLE of the endocrine factor in the pathogenesis of psychosis has long been postulated. The possible relation of endocrine dysfunction to mental disorder may be seen in different ways: 1. The endocrine disorder may cause the mental disease. 2. The endocrine disorder may be a result of the mental disease. 3. The mental disease may be psychogenic, or in response to worry over the physical changes induced by the gland. 4. The mental disease and glandular dysfunction may coexist independently. Special attention has been given to the anterior lobe of the pituitary and the adrenal cortex.
Functional disturbances may be correlated with hyperfunction, hypofunction, dysfunction, or disequilibrium of the endocrine system. Castor and associates1 gave large doses of cortisone to rats and found, on microscopic examination, evidence of damage to the thalamus, hypothalamus, and cerebral cortex. In Cushing's syndrome (adrenal cortex hyperfunction), which is due to a tumor
ALEXANDER SP, NEANDER JF. ADRENOCORTICAL RESPONSIVITY TO ELECTRIC SHOCK THERAPY AND INSULIN THERAPYA Study of Fifty-Six Mentally III Patients in Rockland State Hospital, Orangeburg, N. Y.. AMA Arch NeurPsych. 1953;69(3):368–374. doi:10.1001/archneurpsyc.1953.02320270089009
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