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August 1953

CEREBRAL CIRCULATION AND METABOLISM IN MULTIPLE SCLEROSIS: Correlative Observations by Electroencephalography and Psychodiagnostic Testing

Author Affiliations


From the Department of Physiology, University of Miami School of Medicine, and the Departments of Neurology and Psychiatry, Veterans Administration Hospital.

AMA Arch NeurPsych. 1953;70(2):260-267. doi:10.1001/archneurpsyc.1953.02320320126011

THE ETIOLOGY and pathologic physiology of multiple sclerosis have remained obscure despite many excellent clinical and pathologic observations. Hypotheses which incriminate vascular spasm and venular thrombosis as factors mechanically responsible for the lesions of multiple sclerosis have incited considerable clinical investigation1 and have provided the main basis for therapy of acute stages of the disease, namely, the use of so-called cerebral vasodilator drugs and drugs to inhibit formation of vascular thrombi.2 One of the purposes of the present study, therefore, was to measure cerebral blood flow and metabolism in patients in various stages of multiple sclerosis in an effort to detect the possible presence of alterations in cerebral circulation and metabolism which might presumably be produced by vascular spasm or clotting. Simultaneously, it was hoped to determine whether the known pathological lesions in the brain in multiple sclerosis, whatever their cause, result in measurable alterations in cerebral blood

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