NEW AND more effective means of chemotherapy for mental disorders are constantly being sought by psychiatrists. The advent of mechanotherapy, such as electric shock therapy, has stimulated rather than deterred this search. With this in mind, it was noted that elevation of mood and euphoria were reported in the literature1 as side-effects when patients with tuberculosis were treated with isoniazid. Accordingly, plans were made to study the effect of this drug on a group of depressed but nontuberculous patients seen in private psychiatric practice.
Actually, isoniazid is not new, having been synthesized in 1912,2 but its recognized success against tuberculosis has been of but two years' duration. In addition to being a potent tuberculostatic agent, recently it has been used with increasing frequency in conditions other than pulmonary disease.
However, only a few reports have appeared on the use of isoniazid in the field of psychiatry. One of
SALZER HM, LURIE ML. ANXIETY AND DEPRESSIVE STATES TREATED WITH ISONICOTINYL HYDRAZIDE (ISONIAZID). AMA Arch NeurPsych. 1953;70(3):317–324. doi:10.1001/archneurpsyc.1953.02320330042005
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