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November 1953

Cerebral Changes Following Electrically Induced Convulsions: An Experimental Study on Cats

AMA Arch NeurPsych. 1953;70(5):685-686. doi:10.1001/archneurpsyc.1953.02320350137016

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Studies published by previous authors have been contradictory as to the changes in the brain following electric shock; so the author has reviewed the literature and undertaken a controlled investigation, using cats and preparing the material with rigorous precautions against accepting artifacts and incidental findings. The fact that he made no mistakes when separating those animals who had undergone electrically induced convulsions from those who had received none is a credit to the perspicacity of the investigator. And yet the changes, such as they are, are not of a kind to meet the wandering or inattentive eye. Some sections were insufficiently demonstrative, while others were misleading, so that a number of slides had to be seen and then reviewed, new ones cut and stained, and, finally, when the changes were well fixed in the mind of the investigator, the sections examined a third time "blind," and even a fourth time,

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