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February 1954

NEUROLOGICAL AND ELECTROENCEPHALOGRAPHIC EFFECTS OF X-IRRADIATION OF THE HEAD IN MONKEYS

Author Affiliations

LOS ANGELES

From the Department of Anatomy, University of California School of Medicine at Los Angeles, and the Veterans Adminstration Hospitals, Long Beach and Los Angeles (Sawtelle), Calif.

AMA Arch NeurPsych. 1954;71(2):238-249. doi:10.1001/archneurpsyc.1954.02320380104012
Abstract

THE ADULT nervous system is highly resistant to ionizing radiation at dosage levels which severely injure other tissues.* In support of this generalization Eldred and Trowbridge have recently found that x-irradiation of monkeys with totalbody doses of 400 to 800 r failed to induce neurological changes,3 although radiation sickness and death occurred.4

It has been shown, however, that higher doses of radiation, when restricted to the heads of monkeys, may result in weakness, apathy, hemiparesis, and hemiplegia.5 Similarly, tremors, clonic twitching, and epileptoid seizures have been seen after irradiation of the brains of puppies.† Lyman, Kupalov, and Scholz8 and Nemenov ‡ believed that irradiation of the head in dogs caused impairment of reflex conditioning (Pavlov), while Warren10 reported a "depression" of the nervous system in rats after 1,500 r total-body exposure. These investigations, together with case reports in man,ß indicate that the central nervous system

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