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April 1954

STUDY OF HUMAN CEREBRAL BIOPSY SPECIMENS IN AN ELECTRICALLY EXCITED CONDITION

AMA Arch NeurPsych. 1954;71(4):488-495. doi:10.1001/archneurpsyc.1954.02320400084008
Abstract

MEANS of electrically stimulating the metabolism of separated cerebral tissues have recently been developed in these laboratories.* The methods render such tissue much more susceptible to a wide variety of agents than are unstimulated tissues.3 and metabolic lesions, otherwise unapparent, may thus be detected. The methods are applicable to a few milligrams of tissue taken as biopsy specimens or during neurosurgical operations. They have not yet found a routine use, but their value in research is indicated by the following account, which describes briefly some results previously reported and adds others hitherto unpublished.

A separated fragment of the mammalian cerebral cortex is electrically inert when examined by techniques which reveal profuse and intricate electrical activity in the brain in situ. A few seconds only after such a fragment has been removed from the brain, not only will it give no electrical response to applied electrical pulses, but also the

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