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April 1954

CLOT RETRACTION TIME AS A DIAGNOSTIC AID IN NEUROLOGY

Author Affiliations

CINCINNATI; NEW YORK

From the Division of Neuropsychiatry, Montefiore Hospital.

AMA Arch NeurPsych. 1954;71(4):496-500. doi:10.1001/archneurpsyc.1954.02320400092009
Abstract

AN INCREASED adhesiveness of the platelets has been observed in a number of physiological and pathological conditions.* Common to almost all these various conditions is an abnormally rapid growth of tissue occurring at any place in the body.4 This is particularly well demonstrated by the presence of an elevated platelet adhesiveness in the postoperative period,† in the presence of both benign and malignant neoplasms,‡ and during a reticulocyte response to antianemic therapy.4 An elevated platelet adhesiveness has been found associated with active multiple sclerosis, brain and spinal cord tumors, and the Guillain-Barré syndrome.5 In the same study a normal platelet adhesiveness was found in infections, in vascular accidents, including thromboembolic phenomena, and in degenerative diseases of the nervous system.

The platelet adhesiveness has been shown to be closely correlated with the rate of initiation of clot retraction as measured by the clot retraction time.6 An elevated

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