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May 1954

EFFECT OF PINEAL EXTRACTS ON BLOOD GLUTATHIONE LEVEL IN PSYCHOTIC PATIENTS

AMA Arch NeurPsych. 1954;71(5):615-618. doi:10.1001/archneurpsyc.1954.02320410077006
Abstract

THE FUNCTION of the pineal gland is not established; evidence bearing on this matter has been reviewed in another publication from this laboratory.1 The possibility that the pineal gland might influence metabolism in man has not been investigated extensively in the past, and it was therefore decided to make such a study here. Some negative findings were encountered; a constant positive finding was that the blood glutathione level changed during a course of injections of some pineal extracts. This was considered important since earlier work2 had shown that the blood glutathione level is low in many patients with manic-depressive, involutional, or schizophrenic psychoses. A few observations on glucose tolerance were also made, in view of the belief currently held by some workers that glutathione influences carbohydrate metabolism.

MATERIAL AND METHODS  Nine experiments were performed with four pineal extracts, designated in this laboratory as A, RPA-4, TRPA-4, and TSD-D;

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