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June 1954

SUITABILITY OF TUMOR-BEARING MICE FOR PREDICTING RELATIVE USEFULNESS OF ISOTOPES IN BRAIN TUMORS: Comparative Clinical and Laboratory Study in Localization and Treatment of Brain Tumors with P32, Na24, K42, and Sodium Borate

Author Affiliations


From the Department of Surgery, Harvard Medical School, and the Department of Neurosurgery, Massachusetts General Hospital.

AMA Arch NeurPsych. 1954;71(6):684-698. doi:10.1001/archneurpsyc.1954.02320420012002

IN CONNECTION with investigations being pursued in this laboratory on the application of atomic energy methods to the diagnosis, localization, and treatment of brain tumors,1 it has been necessary to screen a variety of radioactive isotopes and compounds of stable isotopes having useful nuclear properties, to determine which among them possess superior biological characteristics in regard to concentration in brain, brain tumor, and muscle.

This screening of isotopes was carried out at first mainly in selected brain tumor patients. However, the paucity of suitable patients, the wide variations in their physiological status, the variety of tumor types encountered, and the frequent compromises of experimental discipline imposed by transcendent clinical necessity rendered this method of study slow, tedious, and at times difficult to interpret. As a means of circumventing these problems, it occurred to us that most of the desired information about a given isotope might be obtained through carefully

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