IN PREVIOUS papers we have reported that when the dog is used as an experimental animal the common carotid blood flow and arterial pressure responses to electroconvulsive shock and experimental concussion are similar.* Under the conditions of these experiments we inferred that the observed changes in common carotid blood flow were indicative of cerebral blood flow variations.2 To test this hypothesis, a series of experiments were performed with electroconvulsive shock on rhesus macaque monkeys.3 Measurement of the internal carotid blood flow in these animals indicates the status of cerebral blood flow.4 The pattern of flow and pressure changes following electroconvulsive shock in the monkeys was similar to that obtained in dogs.3 Furthermore, the pattern of arterial pressure responses following electroconvulsive shock therapy in psychotic patients is similar in time and direction of change to the pattern observed in dogs and monkeys after such stimuli.5
BROWN GW, BROWN ML. CARDIOVASCULAR RESPONSES TO EXPERIMENTAL CEREBRAL CONCUSSION IN THE RHESUS MONKEY: Discussion of Similarity of Responses to Electroconvulsive Shock and Cerebral Concussion in Dogs, Monkeys, and Man. AMA Arch NeurPsych. 1954;71(6):707–713. doi:10.1001/archneurpsyc.1954.02320420035004
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