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August 1954

METASTASIS OF NEOPLASMS TO THE CENTRAL NERVOUS SYSTEM AND MENINGES

Author Affiliations

NEW YORK

From the Laboratory, Neuropsychiatric and Neoplastic Divisions, Montefiore Hospital.

AMA Arch NeurPsych. 1954;72(2):133-153. doi:10.1001/archneurpsyc.1954.02330020001001
Abstract

THERE ARE few reports of metastatic neoplasms in the central nervous system and meninges based on study of a large series of complete necropsies. An unusually large number of such examinations on patients with cancer was available at Montefiore Hospital. An analysis of the findings in this group is presented.

MATERIAL  During the period from 1938 to 1947, there were 595 complete necropsies performed upon patients who died with cancer. In all these instances the brain was examined, but the spinal cord was studied in only 76 cases. Cases without cancer and those in which examination of the central nervous system was not performed were excluded from consideration in this paper. Metastatic lesions in the central nervous system or meninges were found in 207 cases (35% of the total of 595 necropsies).The primary and metastatic tumors were studied with hematoxylin and eosin preparations in all cases. Special stains, including

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