THE PRESENT study was undertaken in order to examine the effect on cats of intracisternally administered cortisone acetate. The investigation was considered to be both of theoretical and of practical interest in view of the effect of cortisone on normal function, as well as its influence in certain pathological conditions of the nervous system. This investigation includes acute and chronic experiments and pathological examinations.
(a) Acute Experiments.—
This group consisted of eight cats. The experiments were conducted with pentobarbital (Nembutal) anesthesia, 20 mg. of the anesthetic being administered per kilogram of body weight, and the duration of the experiments was from two to three hours. Blood pressure, from the femoral artery, respiration, and electroencephalographic tracings, taken from two symmetrical parietal electrodes, were recorded throughout the experiments. A number of experiments were performed on the same animal at intervals of one hour, at which times the blood pressure and respiration
SAMUELOFF M, FELDMAN S. EFFECT OF CORTISONE ACETATE ADMINISTERED INTRACISTERNALLY IN CATS. AMA Arch NeurPsych. 1954;72(5):599–604. doi:10.1001/archneurpsyc.1954.02330050069011
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