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December 1954

CARBOHYDRATE METABOLISM IN BRAIN DISEASE: III. Fructose Metabolism in Schizophrenic, Manic-Depressive, and Involutional Psychoses

Author Affiliations


From the Laboratory of Clinical Physiology, McLean Hospital, Waverley, Mass., and the Department of Medicine, Harvard Medical School.

AMA Arch NeurPsych. 1954;72(6):696-704. doi:10.1001/archneurpsyc.1954.02330060032005

STUDIES made in this laboratory have demonstrated that abnormalities in the intermediary metabolism of orally and intravenously administered glucose occur in patients with schizophrenia, manic-depressive psychoses, and involutional melancholia.1 These defects appear to constitute a metabolic error that impairs the peripheral oxidation of the small carbohydrate fragments. There has been no thorough investigation of fructose metabolism in these psychoses, although fragmentary studies have been reported.2 The metabolic pathways of glucose and fructose are not entirely the same, and, therefore, the intermediary metabolism of fructose in the psychotic patients might not show the abnormalities exhibited when such patients receive glucose.

MATERIAL AND METHODS  The material and methods were the same as those described previously.1 Pure fructose in doses of 50 or 100 gm. was dissolved in 200 cc. of distilled water and administered by mouth; in other experiments 50 gm. of pure fructose, as a 10% solution, was

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