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January 1955

STUDIES ON BLOOD-BRAIN BARRIER WITH RADIOACTIVE PHOSPHORUS: V. Effect of Cerebral Injuries and Infarction on the Barrier

Author Affiliations


From the Department of Neurosurgery, Massachusetts General Hospital.

AMA Arch NeurPsych. 1955;73(1):2-12. doi:10.1001/archneurpsyc.1955.02330070004002

PREVIOUS investigations revealed the existence of a physiological barrier which prevents the central nervous system from incorporating a large percentage of the P32 made available to the organism by intravenous administration. Data are now accessible1 which cover the P32 uptake from the blood by different parts of the normal mammalian brain at various intervals after the injection of the tracer. The exact mechanism of this process and the structure of the barrier are not known as yet, and hypotheses have to be relied upon. However, data collected under normal circumstances in the past years represent a solid enough basis on which the evaluation of changes in the blood-brain barrier, under pathological conditions, can be attempted.

Practical utilization of the blood-brain barrier concept, with the barrier investigated by radioactive isotopes and, to a less extent, by vital dyes, is carried out successfully in the diagnosis and localization of