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January 1955

ADRENOCORTICAL FUNCTION AND URINARY PHOSPHATE EXCRETION: Comparison in Schizophrenia and in Lysergic Acid Diethylamide-Induced Psychotic Episodes in Normal Persons

Author Affiliations

Shrewsbury, Mass.; Boston

From the Worcester Foundation for Experimental Biology, Shrewsbury, Mass., and the Boston Psychopathic Hospital (Dr. Harry C. Solomon, Director).

AMA Arch NeurPsych. 1955;73(1):100-109. doi:10.1001/archneurpsyc.1955.02330070102011
Abstract

LYSERGIC acid diethylamide (LSD) has come to be regarded with interest in recent years because of its ability to produce hallucinations and other psychotic disturbances when administered to human subjects in exceedingly small doses.* Its activity in amounts of the order of 0.5 γ per kilogram of body weight suggests that it may act as an antimetabolite at a specific site and on a specific enzyme system.

In this paper we wish particularly to consider effects of LSD on aspects of phosphorus metabolism and to compare these data with similar properties in schizophrenic patients.

URINARY INORGANIC PHOSPHATE CHANGES IN RELATION TO ADRENOCORTICAL FUNCTION IN NORMAL MEN AND IN SCHIZOPHRENIC PATIENTS  In a series of studies from the Worcester Foundation carried out in collaboration with the Worcester State Hospital, Pincus, Hoagland, and associates † have reported certain abnormalities in phosphorus metabolism of schizophrenic patients, particularly in relation to the action of

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