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January 1955


Author Affiliations

Washington, D. C.

AMA Arch NeurPsych. 1955;73(1):110-117. doi:10.1001/archneurpsyc.1955.02330070112012

ADVANCE in the therapy of schizophrenia has been handicapped by the lack of a satisfactory understanding, or even a satisfactory working hypothesis, of the nature of the disorder itself. The purpose of this paper is to discuss a working hypothesis and to consider its relation to methods of treatment known to be effective, as well as its possible implications for further or additional methods of treatment. The hypothesis arises in part from a synthesis of ideas borrowed from Hughlings Jackson with ideas borrowed from Eugen Bleuler. It was stimulated particularly by the frustration experiments conducted with rats by Maier1 and by the results of the Veterans Administration lobotomy research project.*

Human evolution has been in large part a process of adding to the basic animal equipment and behavior higher mental processes centered in recently evolved and highly developed brain structures. In place of depending on the slow adaptation of