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February 1955


Author Affiliations

Cambridge, England

AMA Arch NeurPsych. 1955;73(2):124-126. doi:10.1001/archneurpsyc.1955.02330080002002

I. THE NEUROHYPOPHYSIS  THE NEUROHYPOPHYSIS and the adrenal medulla are the only two endocrine glands dependent on a secretory nerve supply for their functional activity. It is only within relatively recent years that the mechanisms controlling the secretion in the neurohypophysis have been worked out. Observations of Ramón y Cajal, Pines, and Greving defined the tract of unmyelinated nerve fibers running from the paraventricular and supraoptic nuclei to the neurohypophysis. Ranson and his colleagues observed that fibers comprising the tuberohypophysial tract, of uncertain origin, ran in the dorsal wall of the hypothalamohypophysial tract, most of whose fibers came from the supraoptic nucleus. Lesions of the supraopticohypophysial tract made with the Horsley-Clarke stereotaxic instrument in cats were shown by Fisher, Ingram, and Ranson to lead to diabetes insipidus controllable by posterior pituitary extracts. Morphologically, atrophy of the neurohypophysis occurred, and the median eminence and infundibular stem and process became shrunken and