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February 1955

SECRETION OF ANTIDIURETIC HORMONE IN RESPONSE TO NOXIOUS STIMULI

Author Affiliations

Pittsburgh

From the Department of Clinical Science, University of Pittsburgh School of Medicine.

AMA Arch NeurPsych. 1955;73(2):135-137. doi:10.1001/archneurpsyc.1955.02330080013005
Abstract

THE CLASSIC studies of Verney and his associates reveal that exposure to physical or emotional stimuli which are noxious to animal or man results in an inhibition of the diuresis induced by the ingestion of water. A marked diminution in the rate of urine production occurs in animals exposed to such varied stimuli as severe exercise, surgical trauma, mechanical shaking, flashing lights, histamine, and so forth. In fact, the same stimuli which can initiate the sequence of events described by Selye as the "alarm reaction" elicit also an antidiuretic response. Extracts from the hypothalamus of such stressed animals exhibit a marked diminution in the concentration of antidiuretic hormone.

Direct evidence that an increase in the antidiuretic activity of the blood occurs when an animal is exposed to a noxious stimulus was not available until recently. With the development of a relatively simple, sensitive, and precise procedure for the assay of

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