THE CLASSIC studies of Verney and his associates reveal that exposure to physical or emotional stimuli which are noxious to animal or man results in an inhibition of the diuresis induced by the ingestion of water. A marked diminution in the rate of urine production occurs in animals exposed to such varied stimuli as severe exercise, surgical trauma, mechanical shaking, flashing lights, histamine, and so forth. In fact, the same stimuli which can initiate the sequence of events described by Selye as the "alarm reaction" elicit also an antidiuretic response. Extracts from the hypothalamus of such stressed animals exhibit a marked diminution in the concentration of antidiuretic hormone.
Direct evidence that an increase in the antidiuretic activity of the blood occurs when an animal is exposed to a noxious stimulus was not available until recently. With the development of a relatively simple, sensitive, and precise procedure for the assay of
MIRSKY A. SECRETION OF ANTIDIURETIC HORMONE IN RESPONSE TO NOXIOUS STIMULI. AMA Arch NeurPsych. 1955;73(2):135–137. doi:10.1001/archneurpsyc.1955.02330080013005
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