ALTERATIONS in the proteins * of the cerebrospinal fluid (CSF), and in the cell count and the colloidal reactions,4 occur in an appreciable proportion of patients with multiple sclerosis. Observation of these changes has proved to have some diagnostic importance, although normal findings in the CSF often enhance the probabilities in favor of multiple sclerosis in differential diagnosis.5 There are also reports † of statistically significant alterations in plasma proteins associated with this disease.
The present study deals with the free amino acids of the CSF and was undertaken with the thought that qualitative or quantitative changes might be found which would be of value in the diagnosis of multiple sclerosis or in explaining its cause or causes. This expectation was not realized, but new information has been obtained concerning the free amino acids of the normal CSF and changes observed in neurological disorders other than multiple sclerosis.
WALKER BS, TELLES NC, PASTORE EJ. AMINO ACIDS OF THE CEREBROSPINAL FLUID: Normal Paper Chromatographic Pattern and Its Duplication in Multiple Sclerosis. AMA Arch NeurPsych. 1955;73(2):149–157. doi:10.1001/archneurpsyc.1955.02330080027009
Customize your JAMA Network experience by selecting one or more topics from the list below.