[Skip to Navigation]
Other
February 1955

EFFECT OF LARGACTIL (CHLORPROMAZINE) ON HUMAN SPASTICITY AND ELECTROMYOGRAM: Preliminary Report

Author Affiliations

Toronto, Canada

From the Department of Anatomy, University of Toronto, and the Ontario Hospital.

AMA Arch NeurPsych. 1955;73(2):224-231. doi:10.1001/archneurpsyc.1955.02330080102019
Abstract

THE PURPOSE of this paper is to present the electromyographic results of the intravenous administration of chlorpromazine (Largactil) to patients with spasticity due to an upper motor neuron lesion. Although only 13 patients have been studied to date, the results have been so dramatic that they deserve early reporting, especially since the effect of chlorpromazine on spasticity has not been described previously. Moreover, we have reason to believe that chlorpromazine may be effective in other motor disturbances (e. g., tremors) and so merits a wider trial outside its present restricted field of anesthesia and psychiatry. No attempt will be made here to review the rapidly expanding literature on chlorpromazine, nor will the chemistry be discussed. These matters are dealt with adequately in recent papers by Anton-Stephens1; Delay, Deniker, and Harl4; Lehmann and Hanrahan,10 and Terzian.14

After the observation by one of us (A. S.) that a

×