VARIOUS gross changes in the retinal blood vessels in cases of multiple sclerosis have been described in recent years. They are visible opthalmoscopically. So far, microscopic changes have not been described, nor has there been any recorded opportunity to look for them.
Rucker has reported "venous sheathings," which give the appearance of perivenous white, thickened tissue. His photographs suggest narrowing of the vessels at the sheathed areas.* Rucker did not study associated visual function or disturbance.
With Franklin, I have described narrowed areas in both retinal arterioles and venules (Fig. 1). There were associated visual defects; most of them were so located as to be explicable by the constrictions. Frequently, also, rapidly acting vasodilating drugs promptly reduced or abolished the visual disturbances, at least temporarily. The effect of these drugs upon the constricted areas of the vessels was less certain, although frequently Franklin thought he saw a widening; the vascular
BRICKNER RM. PHENOMENON OF RELIEF BY FLUSH IN MULTIPLE SCLEROSIS: Its Use As a Foundation for Therapy. AMA Arch NeurPsych. 1955;73(2):232–240. doi:10.1001/archneurpsyc.1955.02330080110020
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