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March 1955

Cerebrospinal Fluid Inorganic Phosphorus in Acute Poliomyelitis: Study of One Hundred Four Patients

Author Affiliations

New York; Brooklyn

From the Communicable Disease and Laboratory Services of the Kingston Avenue Hospital, 600 Albany Ave., Brooklyn.

AMA Arch NeurPsych. 1955;73(3):255-266. doi:10.1001/archneurpsyc.1955.02330090001001

Phosphorus, in the form of phosphate, is one of the largest and most important constituents of central nervous system tissue, and therefore its determination in cerebrospinal fluid, which has been made rarely in poliomyelitis, might provide information on the diagnosis, course, and treatment of the disease. During the 1952 epidemic of poliomyelitis inorganic phosphorus levels in 110 cerebrospinal fluids were determined on 104 patients during the acute phase, and this report evaluates the findings. There was a previous report of cerebrospinal fluid inorganic phosphorus in four poliomyelitis patients by Wilcox, Lyttle, and Hearn1 in 1925.


Patient Material.  —During the 1952 poliomyelitis epidemic, 255 patients were hospitalized with poliomyelitis in the Kingston Avenue Hospital, the communicable diseases hospital for the nearly 3,000,000 people of the borough of Brooklyn. From the time (July 9, 1952) that determinations of cerebrospinal fluid inorganic phosphorus levels were started in poliomyelitis patients,