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March 1955

Blood Platelets in Disseminated Sclerosis: Quantitative Variations in Peripheral Blood

Author Affiliations


From the Neuromedical Department, Rigshospitalet (Prof. Mogens Fog) and from the University Institute for Human Genetics (Prof. Tage Kemp).

AMA Arch NeurPsych. 1955;73(3):267-285. doi:10.1001/archneurpsyc.1955.02330090013002

The peripheral blood of patients with disseminated sclerosis has been examined with a view of studying blood platelet variations. We have concentrated particularly on blood platelet counts for the reason that blood platelet agglutinations have been noted in the blood vessels in encephalomyelitic foci. These agglutinations may, of course, be regarded as agonal, but the possibility of intravital agglutinations exists, and the probability of such a phenomenon would become greater if variations in the total blood platelet system of the organism, with a tend-ency to increased agglutination, could be demonstrated in patients with the disease. Recognition of the stated agglutinations is a result of the great interest taken in the vascular condition in disseminated sclerosis, in which the degenerative and reactive tissue changes have been found to bear a pronounced relation to the venous system (Putnam,* Broman,4 Fog,f Haarr8).

MATERIAL AND METHODS  The material comprises 103 cases of