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April 1955

Experimentally Induced Hypotension: Clinical and Electroencephalographic Consequences

Author Affiliations

Washington, D. C.

From the Department of Neurology, George Washington University School of Medicine and the District of Columbia General Hospital.

AMA Arch NeurPsych. 1955;73(4):416-424. doi:10.1001/archneurpsyc.1955.02330100048009

The neurologist is frequently confronted with the problem of syncope and with determining its etiology. Postural hypotension is a possible cause that is considered only rarely in this connection, and the neurological literature is scanty on this subject, although many articles have appeared since its description in 1925 by Bradley and Eggleston.1 It is of further interest that neurological disease may be the primary disorder responsible for the orthostatic hypotension, e. g., syphilis of the central nervous system or syringomyelia.

The objective in this investigation was to devise a reliable and reproducible method of effectively, promptly, and safely producing a controllable hypotension, and to observe the associated clinical and electroencephalographic changes. Previous studies2 had demonstrated the efficacy of the technique of placing a subject on a tilt table, injecting hexamethonium intravenously (1 cc/min. of a 2% solution), and raising or lowering the head of the table to obtain

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